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The primary endpoint with the review was the prevalence of to start with stroke (possibly ischemic or hemorrhagic) or of a systemic embolic function (SEE) that happened during treatment or inside of three times from the last dose taken. In the overall results in the study, proven in Desk fourteen.1, equally cure arms of SAVAYSA have been non-inferior to warfarin for the first efficacy endpoint of stroke or SEE. However, the 30 mg (fifteen mg dose-decreased) therapy arm was numerically less efficient than warfarin for the main endpoint, and was also markedly inferior in decreasing the speed of ischemic stroke.

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c GUSTO – Significant or existence-threatening bleeding that caused hemodynamic compromise and calls for intervention

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